Micro surgical instrument and loading unit for use therewith

ABSTRACT

A loading unit configured for engagement with a surgical instrument is disclosed. The loading unit comprises a proximal body portion and a tool assembly. The proximal body portion defines a longitudinal axis. The tool assembly is disposed in mechanical cooperation with the proximal body portion and includes a cartridge assembly and an anvil assembly. At least one of the cartridge assembly and the anvil assembly is movable with respect to the other between an open position and an approximated position to engage tissue therebetween. The cartridge assembly is configured to house a plurality of fasteners therein. The diameter of the tool assembly is less than or equal to about 8 mm.

BACKGROUND

1. Technical Field

The present disclosure relates generally to instruments for surgically joining tissue and, more specifically, to a surgical fastening instrument and a loading unit including an end effector having a relatively small diameter.

2. Background of Related Art

Various types of surgical instruments used to surgically join tissue are known in the art, and are commonly used, for example, for closure of tissue or organs in transection, resection, anastomoses, for occlusion of organs in thoracic and abdominal procedures, and for electrosurgically fusing or sealing tissue.

One example of such a surgical instrument is a surgical stapling instrument, which may include an anvil assembly, a cartridge assembly for supporting an array of surgical fasteners, an approximation mechanism for approximating the cartridge and anvil assemblies, and a firing mechanism for ejecting the surgical fasteners from the cartridge assembly.

Using a surgical instrument, it is common for a surgeon to approximate the anvil and cartridge members. Next, the surgeon can fire the instrument to emplace fasteners in tissue. Additionally, the surgeon may use the same instrument or a separate instrument to cut the tissue adjacent or between the row(s) of fasteners.

Additionally, a single use loading (“SULU”) or a disposable loading unit (“DLU”) may be attached to an elongated or endoscopic portion of a surgical stapling instrument. Such loading units allow surgical stapling instruments to have greater versatility, for example. The loading units may be configured for a single use, and/or may be configured to be used more than once.

Further, end effectors and/or loading units are generally limited in size by various components contained therein. That is, while there may be a need for end effectors and/or loading units having diameters that are smaller than those typically available, the diameter of the end effector and/or loading unit is typically limited by the size, geometry and/or orientation of the staple pushers, I-beam, actuation sled, and fasteners, for example, contained therein.

SUMMARY

The present disclosure relates to a loading unit configured for engagement with a surgical instrument. The loading unit comprises a proximal body portion and a tool assembly. The proximal body portion defines a longitudinal axis. The tool assembly is disposed in mechanical cooperation with the proximal body portion and includes a cartridge assembly and an anvil assembly. At least one of the cartridge assembly and the anvil assembly is movable with respect to the other between an open position and an approximated position to engage tissue therebetween. The cartridge assembly is configured to house a plurality of fasteners therein. The diameter of the tool assembly is less than or equal to about 8 mm.

In disclosed embodiments, the diameter of the tool assembly is equal to about 7 mm.

In disclosed embodiments, a diameter of a portion of the proximal body portion is substantially equal to the diameter of the tool assembly.

In disclosed embodiments, the loading unit further comprises a clamping member disposed in mechanical cooperation with the cartridge assembly and the anvil assembly. Here, the clamping member includes a vertical portion defining a vertical axis and being substantially perpendicular to the longitudinal axis. It is further disclosed that the loading unit further comprises an actuation sled longitudinally translatable at least partially within the cartridge assembly. The actuation sled includes at least two camming surfaces: a first camming surface extends at a first angle with respect to a plane extending through the longitudinal axis and the vertical axis (the vertical axis is within the plane) and a second camming surface extends at a second angle with respect to the plane. It is further disclosed that first angle and the second angle are between about 15° and about 40°, or between about 20° and about 35°. It is further disclosed that the actuation sled includes a V-like profile. It is further disclosed that at least a majority of a first tissue-contacting surface of the cartridge assembly is disposed at a substantially perpendicular angle with respect to the first angle, and at least a majority of a second tissue-contacting surface of the cartridge assembly is a disposed at a substantially perpendicular angle with respect to the second angle.

In disclosed embodiments, the cartridge assembly includes a plurality of fasteners therein. Each of the plurality of fasteners is configured to be ejected from the cartridge assembly at an angle that is neither parallel nor perpendicular to the vertical axis.

In disclosed embodiments, the clamping member includes a top portion for engaging the anvil assembly and a bottom portion for engaging the cartridge assembly. A total height defined between an upper-most surface of the top portion and a lower-most surface of the bottom portion is between about 1 mm and about 2.5 mm, or about 2 mm.

In disclosed embodiments, the loading unit further comprises an actuation sled longitudinally translatable at least partially within the cartridge assembly. The clamping member includes a top portion for engaging the anvil assembly and a bottom portion for engaging the cartridge assembly. A lower-most surface of the bottom portion is closer to the top portion of the clamping member than an upper-most surface of the actuation sled.

The present disclosure also relates to a cartridge assembly for use with a tool assembly of a surgical instrument. The cartridge assembly comprises a plurality of fasteners disposed at least partially therein, and an actuation sled configured for longitudinal translation therein along a first longitudinal axis. Each of the plurality of fasteners is configured to be ejected at a non-perpendicular angle with respect to the first longitudinal axis.

In disclosed embodiments, the actuation sled includes a V-like profile including a first camming surface disposed at a first angle and a second camming surface disposed at a second angle. It is further disclosed that the cartridge assembly comprises a first tissue-contacting surface and a second tissue-contacting surface. At least a majority of the first tissue contacting surface is disposed at a substantially perpendicular angle with respect to the first angle. At least a majority of the second tissue-contacting surface of the cartridge assembly is a disposed at a substantially perpendicular angle with respect to the second angle.

The present disclosure also relates to a surgical instrument comprising a handle assembly, an elongated body portion extending distally from the handle assembly, and a loading unit configured for engagement with a distal end of the elongated body portion. The loading unit comprises a proximal body portion defining a longitudinal axis, and a tool assembly disposed in mechanical cooperation with the proximal body portion. The tool assembly includes a cartridge assembly and an anvil assembly. At least one of the cartridge assembly and the anvil assembly being movable with respect to the other between an open position and an approximated position to engage tissue therebetween. The cartridge assembly is configured to house a plurality of fasteners therein. The diameter of the tool assembly is less than or equal to about 8 mm.

In disclosed embodiments, the surgical instrument further comprises a clamping member disposed in mechanical cooperation with the cartridge assembly and the anvil assembly. The clamping member includes a vertical portion defining a vertical axis and is substantially perpendicular to the longitudinal axis.

In disclosed embodiments, the cartridge assembly includes a plurality of fasteners therein, and each of the plurality of fasteners is configured to be ejected from the cartridge assembly at an angle that is neither parallel nor perpendicular to the vertical axis.

In disclosed embodiments, the surgical instrument includes an actuation sled longitudinally translatable at least partially within the cartridge assembly. The actuation sled includes at least two camming surfaces. A first camming surface extends at a first angle with respect to a plane extending through the longitudinal axis and the vertical axis (the vertical axis is within the plane), and a second camming surface extends at a second angle with respect to the plane. It is further disclosed that the first angle and the second angle are between about 15° and about 40°, or about 20° and about 35°.

BRIEF DESCRIPTION OF FIGURES

Various embodiments of the presently disclosed surgical instruments and loading units are disclosed herein with reference to the drawings, wherein:

FIG. 1 is a perspective view of a surgical instrument including a first handle assembly in accordance with an embodiment of the present disclosure;

FIG. 2 is a perspective view of a surgical instrument including a second handle assembly in accordance with an embodiment of the present disclosure

FIGS. 3 and 4 are perspective views of a loading unit in accordance with the present disclosure;

FIG. 5 is a perspective view of the loading unit of FIGS. 3 and 4 illustrating the end effector disposed in an articulated position;

FIG. 6 is a radial cross-sectional view of a portion of the end effector taken through line 6-6 in FIG. 2;

FIG. 7 is a perspective view of various internal components of the loading unit of FIGS. 3 and 4;

FIG. 8 is a perspective view of the portion of the loading unit indicated in FIG. 7;

FIG. 9 is a perspective view of various internal components of the loading unit of FIGS. 3 and 4;

FIG. 10 is a perspective view of the portion of the loading unit indicated in FIG. 8;

FIG. 11 is an assembly view of a portion of the loading unit;

FIG. 12 illustrates the portion of the loading unit indicated in FIG. 11;

FIG. 13 illustrates the portion of the loading unit indicated in FIG. 11;

FIG. 14 is a perspective view of a portion of the loading unit of the present disclosure;

FIG. 15 illustrates the portion of the loading unit indicated in FIG. 14;

FIG. 16 is a longitudinal cut-away view of a portion of the loading unit as indicated along line 16-16 in FIG. 8;

FIG. 17 is a longitudinal cross-sectional view of a portion of the loading unit; and

FIG. 18 illustrates the portion of the loading unit indicated in FIG. 17.

DETAILED DESCRIPTION

Embodiments of the presently disclosed surgical instrument, loading unit for use therewith, and cartridge assembly for use therewith, are described in detail with reference to the drawings, wherein like reference numerals designate corresponding elements in each of the several views. As is common in the art, the term “proximal” refers to that part or component closer to the user or operator, e.g., surgeon or physician, while the term “distal” refers to that part or component farther away from the user.

A surgical instrument of the present disclosure is indicated as reference numeral 100 in FIGS. 1 and 2. Generally, surgical instrument 100 includes a handle assembly 110, an elongated body portion 120 extending distally from handle assembly 110, and a loading unit 200 disposed adjacent a distal end of elongated body portion 120. FIG. 1 illustrates surgical instrument 100 including a first handle assembly 110 (e.g., a powered handle assembly), and FIG. 2 illustrates surgical instrument 100 including a second handle assembly 110. It is also envisioned that other types of handles can be used such as, for example, motor-driven, hydraulic, ratcheting, etc. As used herein, “handle assembly” encompasses all types of handle assemblies. Loading unit 200 is attachable to endoscopic portion 120 of surgical stapling instrument 100, e.g., to allow surgical instrument 100 to have greater versatility. As used herein, “loading unit” encompasses both single use loading units (“SULU”) and disposable loading units (“DLU”). Additionally or alternatively, surgical instrument 100 may have a cartridge which is removable and replaceable in the reusable jaws of the instrument.

Examples of loading units for use with a surgical stapling instrument are disclosed in commonly-owned U.S. Pat. No. 5,752,644 to Bolanos et al., the entire contents of which are hereby incorporated by reference herein. Further details of an endoscopic surgical stapling instrument are described in detail in commonly-owned U.S. Pat. No. 6,953,139 to Milliman et al., the entire contents of which are hereby incorporated by reference herein.

In a surgical instrument 100 in accordance with the present disclosure, a firing rod is moved distally through actuation of handle assembly 110 to deploy fasteners 600. With reference to the embodiment illustrated in FIG. 1, at least a partial actuation of switch 112 translates the firing rod longitudinally. With reference to the embodiment illustrated in FIG. 2, at least a partial actuation of a movable handle 132 with respect a stationary handle 134 translates the firing rod longitudinally. Translation of the firing rod causes translation of a knife bar 140 and translation of a sled bar 150 (see FIGS. 17 and 18, for example; with particular reference to FIG. 18, knife bar 140 includes a proximal section 140 a and a distal section 140 b, which are linked together). Further, translation of knife bar 140 causes translation of a clamping member 500 to approximate at least one jaw member with respect to the other, and translation of sled bar 150 causes translation of an actuation sled 520 to cause fasteners 600 to be ejected from pockets 401 of a cartridge assembly 400.

With reference to FIGS. 3-5, loading unit 200 of the present disclosure is shown. Loading unit 200 includes a proximal body portion 210 defining a longitudinal axis “A-A,” and a tool assembly or end effector 220 including a pair of jaw members (i.e., an anvil assembly 300 and a cartridge assembly 400). Proximal body portion 210 is configured to removably attach to endoscopic portion 120 of surgical instrument 100. More particularly, an insertion tip 202 of loading unit 200 is linearly inserted into the distal end of endoscopic portion 120 of surgical stapling instrument 100. Nubs 204 of insertion tip 202 move linearly through slots formed adjacent the distal end of endoscopic portion 120. Subsequently, loading unit 200 is rotated about the longitudinal axis “A-A” such that nubs 204 move transversely through the slots within endoscopic portion 120. Additionally, during engagement of loading unit 200 and endoscopic portion 120, the firing rod of handle portion 110 engages knife bar 140 of loading unit 200.

With reference to FIG. 6, clamping member 500 includes an I-shaped cross-section, including a top portion 502, which is configured to engage anvil assembly 300, a bottom portion 504, which is configured to engage cartridge assembly 400, and a vertical portion 503, which connects top portion 502 and bottom portion 504 and which may include a cutting edge 506 on its distal surface. More particularly, engagement between bottom portion 504 of clamping member 500 and cartridge assembly 400 helps maintain the relative positions of anvil assembly 300 and cartridge assembly 400 with respect to each other.

With further regard to actuation sled 520, distal translation of actuation sled 520 sequentially engages a plurality of pushers 540, and causes pushers 540 to move toward respective tissue-contacting surfaces 410 of cartridge assembly 400 and eject fasteners 600 towards anvil assembly 300. Subsequent to the ejection of fasteners 600, cutting edge 506 of clamping member 500 may be included on a distal face thereof to sever the stapled tissue.

With reference to FIGS. 6-18, further details of loading unit 200 are illustrated. Generally, the features of loading unit 200 disclosed herein allow loading unit 200 to have a relatively small diameter (e.g., 7 mm-8 mm) as compared with instruments having diameters of about 12 mm. The diameter of the loading unit 200 is measured between a radially outer-most wall of anvil assembly 300 and a radially outer-most wall of cartridge assembly 400 (see FIG. 6). Such a low profile allows loading unit 200 to be inserted into trocars having similar diameters. As can be appreciated, these low profile loading units 200 are useful in pediatric surgeries and/or other thin tissue locations, for example. Additionally, in the illustrated embodiments, a proximal portion 212 of proximal body portion 210 of loading unit 200 is sized and configured to engage an elongated portion of a surgical instrument having a larger-diameter elongated portion 120 (e.g., about 12 mm), thus enabling greater versatility.

With specific reference to FIG. 6, a radial cross-section of loading unit 200 is shown from a distal end. As shown, pushers 540, fasteners 600, a tissue contacting surface 310 of anvil assembly 300, and a tissue contacting surface 410 of cartridge assembly are disposed at a non-perpendicular angle with respect to a plane C-C (FIG. 8). Plane C-C extends through longitudinal axis A-A and through a vertical axis B-B, defined by vertical portion 503 of clamping member 500. Further, vertical axis B-B is within plane C-C. These non-perpendicular angles, and the relative low-profile of clamping member 500 (as compared to clamping members of larger (e.g., 12 mm) instruments), for example, help enable loading unit 200 to have a small diameter. It is envisioned that the total height of clamping member 500 is between about 1 mm and about 2.5 mm, or about 2 mm.

With further reference to FIG. 6 and with additional reference to FIGS. 11-13 and 17-18, further details of loading unit 200 are shown. With particular reference to FIGS. 17 and 18, a cross-section of loading unit 200 is shown and includes knife bar 140, sled bar 150, anvil assembly 300, cartridge assembly 400, clamping member 500 and actuation sled 520. With particular reference to FIGS. 6 and 12, cartridge assembly 400 includes a cartridge 408 (including two halves) and a cartridge channel 409. Cartridge 408 is disposed within cartridge channel 409.

In use, distal translation of the firing rod, as discussed above, forces knife bar 140 to translate distally. Further, distal translation of knife bar 140 causes a protrusion 143 (see FIG. 17) of knife bar 140 to contact a proximal face 151 of sled bar 150, which causes distal translation of sled bar 150. As sled bar 150 moves distally, a distal face 152 of sled bar 150 contacts a camming surface 402 of cartridge assembly 400, which causes cartridge assembly 400 to move toward anvil assembly 300. Additionally, as knife bar 140 moves distally, top portion 502 of clamping member 500 is distally advanced within a slot 304 within anvil assembly 300, and bottom portion 504 of clamping member 500 is distally advanced within a slot 414 within a cartridge channel 409 of cartridge assembly 400 to help stabilize the jaw members with respect to each other and to help maintain a constant gap between the jaw members. Thus, a predetermined amount of distal travel of the firing rod causes approximation and stabilization of jaw members.

Continued advancement of the firing rod and thus knife bar 140, causes continued advancement of sled bar 150 into a proximal face 522 of actuation sled 520, and causes distal movement of actuation sled 520. As actuation sled 520 advances distally, angled camming surfaces 524 thereof (see FIGS. 6 and 12) contact camming surfaces of pushers 540, thus causing pushers 540 to engage fasteners 600, and subsequently cause ejection of fasteners 600 toward respective pockets 320 of anvil assembly 300 (e.g., through tissue held between the jaw members). As shown (e.g., in FIG. 6), actuation sled 520 includes a substantially V-shaped profile. As shown (e.g., in FIG. 12), each pusher 540 includes two, longitudinally-spaced fastener-contacting portions or pusher plates 544 interconnected by connectors 542. Additionally, the continued advancement of the firing rod also causes continued advancement of knife bar 140 and clamping member 200 such that top portion 502 of clamping member 500 continues to travel within slot 304 of anvil assembly 300, and bottom portion 504 of clamping member 500 continues to travel within slot 414 of cartridge channel 409. Additionally, cutting edge 506 of clamping member 500, if included on clamping member 500, severs tissue disposed between the jaw members (and after the tissue has been fastened, as discussed above). The sled cams care desirably arranged to fire all four rows of staples at about the same time to seal the tissue on both sides of the knife slot just prior to the knife cutting the tissue.

As shown, and as discussed above, various features of loading unit 200 are sized and oriented to enable a small diameter (e.g., 7 mm) of loading unit and jaw members. In particular, camming surfaces 524 of actuation sled 520, pushers 540, pockets 401, and fasteners 600 are disposed at a first non-perpendicular angle (e.g., between about 15° and about 40°, or between about 20° and about 35°, with respect to the vertical axis B-B (which extends through the longitudinal axis A-A). Further, tissue contacting surfaces 310, 410 of anvil assembly 300 and cartridge assembly 400, respectively, are disposed at a corresponding, second non-perpendicular angle such that tissue contacting surface 310 is substantially parallel to tissue contacting surface 410 along at least a majority of the entire lengths of each of the respective surfaces, and such that the first non-perpendicular angle and the second non-perpendicular are substantially perpendicular to each other (i.e., fasteners 600 are disposed at an angle that is substantially perpendicular to the angle of tissue contacting surface 310 of anvil 300, for example). Additionally, clamping member 500 is disposed within the space formed by the angle between camming surfaces 524 of actuation sled 520, and pushers 540 (see FIG. 6).

Referring now to FIGS. 5, 7, 8, 11, 13 and 16, the articulation mechanism of surgical instrument 100 is shown. The articulation mechanism enables end effector 220 of loading unit 200 to be able to pivot with respect to proximal body portion 210 (see FIG. 5). Articulation mechanism includes an articulation lever 700 disposed adjacent elongated body portion 120 (see FIGS. 1 and 2), an articulation link disposed in mechanical cooperation with articulation lever 700, an articulation rod 710 engageable with the articulation link and extending through proximal body portion 210 of loading unit 200 and into engagement with an articulation pin 223 of a proximal portion 222 of end effector 220, and a pivot assembly 720 disposed between proximal body portion 210 and end effector 220 of loading unit 200. With particular reference to FIG. 13, pivot assembly 720 includes a link 722, which pivotably couples a stabilizer 724 of proximal body portion 210 and a link pin 224 (FIG. 16) of proximal portion 222 of end effector 220. Additionally, a pair of clips 730 extends between proximal body portion 210 and end effector 220. As shown in FIG. 8, knife bar 140 extends between clips 730. In certain embodiments, the clips function as blowout plates, with the plates having ends that are fixed in the device.

In use, rotation of articulation lever 700 in a first direction (e.g., counter-clockwise) causes distal movement of the articulation link and articulation rod 710, thus causing end effector 220 to pivot in a first direction (e.g., arrow “C” in FIG. 5) with respect to proximal body portion 210; rotation of articulation lever 700 in a second direction (e.g., clockwise) causes proximal movement of the articulation link and articulation rod 710, thus causing end effector 200 to pivot in a second direction (e.g., opposite arrow “C”) with respect to proximal body portion 210.

The present disclosure also includes a method of using the surgical instrument 100, loading unit 200 and/or cartridge assembly 400, as discussed herein.

While the above description contains many specifics, these specifics should not be construed as limitations on the scope of the present disclosure, but merely as illustrations of various embodiments thereof. Therefore, the above description should not be construed as limiting, but merely as exemplifications of various embodiments. Those skilled in the art will envision other modifications within the scope and spirit of the claims appended hereto. 

1. A loading unit configured for engagement with a surgical instrument, the loading unit comprising: a proximal body portion defining a longitudinal axis; and a tool assembly disposed in mechanical cooperation with the proximal body portion, the tool assembly including a cartridge assembly and an anvil assembly, at least one of the cartridge assembly and the anvil assembly being movable with respect to the other between an open position and an approximated position to engage tissue therebetween, the cartridge assembly being configured to house a plurality of fasteners therein, and wherein the diameter of the tool assembly is less than or equal to about 8 mm.
 2. The loading unit of claim 1, wherein the diameter of the tool assembly is equal to about 7 mm.
 3. The loading unit of claim 1, wherein a diameter of a portion of the proximal body portion is substantially equal to the diameter of the tool assembly.
 4. The loading unit of claim 1, further comprising a clamping member disposed in mechanical cooperation with the cartridge assembly and the anvil assembly, wherein the clamping member includes a vertical portion defining a vertical axis and being substantially perpendicular to the longitudinal axis.
 5. The loading unit of claim 4, further comprising an actuation sled longitudinally translatable at least partially within the cartridge assembly, the actuation sled including at least two camming surfaces, wherein a first camming surface extends at a first angle with respect to a plane extending through the longitudinal axis and the vertical axis, wherein the vertical axis is within the plane, and wherein a second camming surface extends at a second angle with respect to the plane.
 6. The loading unit of claim 5, wherein the actuation sled includes a V-like profile.
 7. The loading unit of claim 5, wherein the first angle and the second angle are between about 15° and about 40°.
 8. The loading unit of claim 5, wherein the first angle and the second angle are about 25°.
 9. The loading unit of claim 5, wherein at least a majority of a first tissue-contacting surface of the cartridge assembly is disposed at a substantially perpendicular angle with respect to the first angle, and wherein at least a majority of a second tissue-contacting surface of the cartridge assembly is a disposed at a substantially perpendicular angle with respect to the second angle.
 10. The loading unit of claim 4, wherein the cartridge assembly includes a plurality of fasteners therein, and wherein each of the plurality of fasteners is configured to be ejected from the cartridge assembly at an angle that is neither parallel nor perpendicular to the vertical axis.
 11. The loading unit of claim 4, wherein the clamping member includes a top portion for engaging the anvil assembly and a bottom portion for engaging the cartridge assembly, and wherein a total height defined between an upper-most surface of the top portion and a lower-most surface of the bottom portion is between about 1 mm and about 2.5 mm.
 12. The loading unit of claim 4, further comprising an actuation sled longitudinally translatable at least partially within the cartridge assembly, wherein the clamping member includes a top portion for engaging the anvil assembly and a bottom portion for engaging the cartridge assembly, and wherein a lower-most surface of the bottom portion is closer to the top portion of the clamping member than an upper-most surface of the actuation sled.
 13. A cartridge assembly for use with a tool assembly of a surgical instrument, the cartridge assembly comprising: a plurality of fasteners disposed at least partially therein; and an actuation sled configured for longitudinal translation therein along a first longitudinal axis; wherein each of the plurality of fasteners is configured to be ejected at a non-perpendicular angle with respect to the first longitudinal axis.
 14. The cartridge assembly of claim 13, wherein the actuation sled includes a V-like profile including a first camming surface disposed at a first angle and a second camming surface disposed at a second angle.
 15. The cartridge assembly of claim 14, further comprising a first tissue-contacting surface and a second tissue-contacting surface, wherein at least a majority of the first tissue contacting surface is disposed at a substantially perpendicular angle with respect to the first angle, and wherein at least a majority of the second tissue-contacting surface of the cartridge assembly is a disposed at a substantially perpendicular angle with respect to the second angle.
 16. A surgical instrument, comprising: a handle assembly; an elongated body portion extending distally from the handle assembly; and a tool assembly including a cartridge assembly and an anvil assembly, at least one of the cartridge assembly and the anvil assembly being movable with respect to the other between an open position and an approximated position to engage tissue therebetween, the cartridge assembly being configured to house a plurality of fasteners therein, and wherein the diameter of the tool assembly is less than or equal to about 8 mm.
 17. The surgical instrument of claim 16, further comprising a clamping member disposed in mechanical cooperation with the cartridge assembly and the anvil assembly, wherein the clamping member includes a vertical portion defining a vertical axis and being substantially perpendicular to the longitudinal axis.
 18. The surgical instrument of claim 17, wherein the cartridge assembly includes a plurality of fasteners therein, and wherein each of the plurality of fasteners is configured to be ejected from the cartridge assembly at an angle that is neither parallel nor perpendicular to the vertical axis.
 19. The surgical instrument of claim 17, further comprising an actuation sled longitudinally translatable at least partially within the cartridge assembly, the actuation sled including at least two camming surfaces, wherein a first camming surface extends at a first angle with respect to a plane extending through the longitudinal axis and the vertical axis, wherein the vertical axis is within the plane, and wherein a second camming surface extends at a second angle with respect to the plane.
 20. The surgical instrument of claim 19, wherein the first angle and the second angle are between about 15° and about 40°.
 21. A surgical instrument comprising: a cartridge assembly and an anvil assembly, at least one of the cartridge assembly and the anvil assembly being movable with respect to the other between an open position and an approximated position to engage tissue therebetween, the cartridge assembly being configured to house a plurality of fasteners therein; an actuation sled having the shape of a wedge; a plurality of pushers arranged in the cartridge assembly so as to be engaged by the actuation sled; a clamping member translatable through the cartridge assembly and anvil assembly; and a sled bar translatable through the cartridge assembly and arranged to move the actuation sled distally through the cartridge assembly so that the actuation sled engages the pushers.
 22. The surgical instrument according to claim 21,wherein the clamping member has an upper portion for engaging the anvil assembly and a lower portion for engaging the cartridge assembly so as to bring the anvil assembly and cartridge assembly into the approximated position.
 23. The surgical instrument according to claim 22, wherein the lower portion engages an upper portion of a cartridge channel.
 24. The surgical instrument according to claim 21, wherein the diameter of the cartridge assembly and anvil assembly when in the approximated position is less than or equal to about 8 mm.
 25. The surgical instrument according to claim 21, wherein the cartridge assembly defines two rows of the fasteners on one side of the clamping member and two rows on the other side of the clamping member.
 26. The surgical instrument according to claim 24, wherein the pushers each have two pusher plates.
 27. The surgical instrument according to claim 21, wherein the clamping member has a knife blade.
 28. The surgical instrument according to claim 21, wherein at least one of the anvil assembly and the cartridge assembly has a non-perpendicular angle. 